Study sheds light on reverse-order heart-liver transplant’s benefits for certain patients

Traditionally, surgeons transplant the heart first followed by the liver. But Mayo Clinic heart transplant team decided to reverse the order for highly sensitised patients in the hopes that the liver would absorb some of the patient’s antibodies, removing them from circulation and lowering the risk of antibody-mediated rejection. The strategy worked, according to a study.

The study was recently published in the Journal of the American College of Cardiology.

All too often, patients with high levels of antibodies face major challenges getting a transplant. These highly sensitized patients have a much higher risk of death while waiting for suitable organs they are less likely to reject. But there is new hope for highly sensitized patients in need of a combined heart and liver transplant, thanks to an innovative surgical approach at Mayo Clinic.

“This unique approach to heart-liver transplant opens the door to more highly sensitized patients getting the transplants they desperately need,” said Sudhir Kushwaha, M.D., a Mayo Clinic cardiologist and the study’s senior author.

More than 107,000 people in the U.S. are on the waitlist for a lifesaving transplant, according to the Organ Procurement and Transplantation Network. An estimated 20 per cent of people waiting for a transplant are highly sensitized, meaning they have high antibody levels that can cause the immune system to reject a transplanted organ. People can become sensitized due to blood transfusions, pregnancies and previous transplants. April is National Donate Life Month, which encourages people to register to be organ, eye and tissue donors, and honour those who have given the gift of life.

The Mayo Clinic team was inspired to try the heart-after-liver transplant procedure after noting that patients who had undergone a traditional heart-liver transplant were much less likely to experience rejection than those who had a heart transplant alone. Previous research has shown a similar phenomenon for patients undergoing a simultaneous kidney-liver transplant.

Mayo Clinic began offering the pioneering heart-after-liver transplant surgery in 2011. The recently published study reviews the outcomes for seven patients who underwent the procedure. The patients were ages 33-51, and six of the seven were women. All experienced a significant drop in antibodies after the procedure was performed, and none of the patients had experienced rejection within four years following surgery. The study’s limitations include its small sample size and younger age of typical transplant patients.

While this new procedure is promising, it comes with major challenges. The heart is usually transplanted first because it is more time-sensitive than other organs. The reverse-order procedure requires a complex choreography between the heart and liver transplant teams to accomplish the procedure.

“Timing is everything. These surgeries require the heart and liver transplant teams to work closely together to limit the time it takes to transplant the donated organs,” said Richard Daly, M.D., a Mayo Clinic cardiothoracic surgeon and the paper’s first author.

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